Karachi

Moenjodaro
An ancient civilization, not to be missed by history buffs
Thatta
Once a famous center of learning, arts, and commerce, as well as a provisional capital for about four centuries. Visit Makli a UN World heritage site, Debal The first Mosque of South Asia was built in 8th Century A.D. by Muhammad Bin Qasim, Jamia Masjid - built by Mughal emperor Shah Jehan -who also built Taj Mahal, Haleji Lake - Famous Birds sanctuary and Sunway Lagoon Waterpark. 55 km away from Karachi.
Keenjhar Lake Resort
16 miles from Thatta on left side is the famous Keenjhar Lake with cottages for overnight stay. Here, travelers can take a break, go boating, bird-watching and fishing. At night you can light beachcombers' torches to extend your enjoyment of the day, before turning in at your cottage. The cottages are booked through Pakistan Tourism Development Corporation PTDC offices located in Karachi on Stratchen Road, opposite Hotel Metropole.
Kirthar National park
An absolutely beautiful park.
Hungol National Park
The biggest park in Pakistan, with sites including volcanoes and remnants of the country's ancient civilizations.
Makran Coastal Highway
Over 770 km From Karachi to Gwadar provides a unique destination for tourists. The highway, which follows the route that Alexander the Great took through the coastal belt of Balochistan in 325 BC, takes you by some of the world’s most beautiful beaches.
Somiani Caves
Spectacular and amazing

Beaches of Gwadar

It is apparently possible to take cargo ships from Karachi to a few ports around the Middle East like Dubai, Oman and other cities

Mumbai
Bombay, the famous bustling city of India is only a short flight from Karachi.